产品名称
Granzyme K Rabbit Polyclonal Antibody
别名
GZMK; TRYP2; Granzyme K; Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3003
Human Swissprot No.
P49863
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49863/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14945
Mouse Swissprot No.
O35205
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35205
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29165
Rat Swissprot Link
http://www.uniprot.org/uniprot/P49864
免疫原
The antiserum was produced against synthesized peptide derived from human GRAK. AA range:61-110
特异性
Granzyme K Polyclonal Antibody detects endogenous levels of Granzyme K protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008],
组织表达
Expressed in lung, spleen, thymus and peripheral blood leukocytes.
细胞定位
Secreted. Cytoplasmic granule.
功能
similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Expressed in lung, spleen, thymus and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
