产品名称
Granuphilin Rabbit Polyclonal Antibody
别名
SYTL4; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin
蛋白名称
Synaptotagmin-like protein 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94121
Human Swissprot No.
Q96C24
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96C24/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27359
Mouse Swissprot No.
Q9R0Q1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0Q1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140594
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8VHQ7
免疫原
The antiserum was produced against synthesized peptide derived from human SYTL4. AA range:381-430
特异性
Granuphilin Polyclonal Antibody detects endogenous levels of Granuphilin protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010],
组织表达
Adrenal gland,Endometrium,Epithelium,Platelet,Spinal cord,Testis,Uterus,
细胞定位
Membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). .
功能
function:Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,similarity:Contains 2 C2 domains.,subcellular location:Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.,subunit:Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
