产品名称
GPT2 Rabbit Polyclonal Antibody
别名
GPT2; AAT2; ALT2; Alanine aminotransferase 2; ALT2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2
蛋白名称
Alanine aminotransferase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84706
Human Swissprot No.
Q8TD30
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TD30/entry
Mouse Swissprot No.
Q8BGT5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGT5
免疫原
Synthesized peptide derived from GPT2 . at AA range: 190-270
特异性
GPT2 Polyclonal Antibody detects endogenous levels of GPT2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
组织表达
Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.
细胞定位
mitochondrion,mitochondrial matrix,
信号通路
Alanine; aspartate and glutamate metabolism;
功能
catalytic activity:L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,pathway:Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.,subunit:Homodimer.,tissue specificity:Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
