产品名称
GPRC5C Rabbit Polyclonal Antibody
别名
GPRC5C; RAIG3; PSEC0087; G-protein coupled receptor family C group 5 member C; Retinoic acid-induced gene 3 protein; RAIG-3
蛋白名称
G-protein coupled receptor family C group 5 member C
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55890
Human Swissprot No.
Q9NQ84
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NQ84/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70355
Mouse Swissprot No.
Q8K3J9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K3J9
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q3KRC4
免疫原
The antiserum was produced against synthesized peptide derived from human GPRC5C. AA range:51-100
特异性
GPRC5C Polyclonal Antibody detects endogenous levels of GPRC5C protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).
细胞定位
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Localized in the plasma membrane and perinuclear vesicles.
功能
function:Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.,induction:By all-trans retinoic acid (ATRA).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the G-protein coupled receptor 3 family.,subcellular location:Localized in the plasma membrane and perinuclear vesicles.,tissue specificity:Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
