产品名称
Cathepsin H Rabbit Polyclonal Antibody
别名
CTSH; CPSB; Pro-cathepsin H
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1512
Human Swissprot No.
P09668
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P09668/entry
Mouse Swissprot No.
P49935
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P49935
免疫原
Synthesized peptide derived from Cathepsin H . at AA range: 220-300
特异性
Cathepsin H Polyclonal Antibody detects endogenous levels of Cathepsin H protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],
组织表达
Cartilage,Eye,Kidney,Liver,Lung,Salivary gland,
功能
catalytic activity:Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
