产品名称
GPR40 Rabbit Polyclonal Antibody
别名
FFAR1; GPR40; Free fatty acid receptor 1; G-protein coupled receptor 40
蛋白名称
Free fatty acid receptor 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2864
Human Swissprot No.
O14842
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14842/entry
Mouse Swissprot No.
Q76JU9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q76JU9
免疫原
The antiserum was produced against synthesized peptide derived from human FFAR1. AA range:185-234
特异性
GPR40 Polyclonal Antibody detects endogenous levels of GPR40 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009],
组织表达
Detected in brain and pancreas. Detected in pancreatic beta cells.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in pancreatic beta cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
