产品名称
GPR27 Rabbit Polyclonal Antibody
别名
GPR27; SREB1; Probable G-protein coupled receptor 27; Super conserved receptor expressed in brain 1
蛋白名称
Probable G-protein coupled receptor 27
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2850
Human Swissprot No.
Q9NS67
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NS67/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14761
Mouse Swissprot No.
O54897
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54897
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65275
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JJH3
免疫原
The antiserum was produced against synthesized peptide derived from human GPR27. AA range:181-230
特异性
GPR27 Polyclonal Antibody detects endogenous levels of GPR27 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010],
组织表达
Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
