产品名称
GPR172A Rabbit Polyclonal Antibody
别名
SLC52A2; GPR172A; PAR1; RFT3; Solute carrier family 52; riboflavin transporter, member 2; Porcine endogenous retrovirus A receptor 1; PERV-A receptor 1; Protein GPR172A; Riboflavin transporter 3; hRFT3
蛋白名称
Solute carrier family 52 riboflavin transporter member 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79581
Human Swissprot No.
Q9HAB3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HAB3/entry
Mouse Swissprot No.
Q9D8F3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D8F3
免疫原
The antiserum was produced against synthesized peptide derived from human PEVR1. AA range:43-92
特异性
GPR172A Polyclonal Antibody detects endogenous levels of GPR172A protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunctio
组织表达
Highly expressed in brain, fetal brain and salivary gland. Weakly expressed in other tissues.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Acts as cell surface receptor for porcine endogenous retrovirus (PERV-A).,similarity:Belongs to the PERVR family.,tissue specificity:Detected in a wide variety of tissues. High expression in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
