BD-PT1964

GPR120 Rabbit Polyclonal Antibody

O3FAR1; GPR120; GPR129; PGR4; Omega-3 fatty acid receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4

常规抗体

O3FAR1

Omega-3 fatty acid receptor 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

338557

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338557

Q5NUL3

http://www.uniprot.org/uniprotkb/Q5NUL3/entry

107221

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107221

Q7TMA4

http://www.uniprot.org/uniprot/Q7TMA4

294075

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294075

Q2AC31

http://www.uniprot.org/uniprot/Q2AC31

The antiserum was produced against synthesized peptide derived from human GPR120. AA range:221-270

GPR120 Polyclonal Antibody detects endogenous levels of GPR120 protein.

WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

38kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],

[Isoform 2]: The predominant isoform in human tissues. Expressed in adipose tissue, pancreatic islets, lung and brain. Expressed in alpha cells of pancreatic islets (PubMed:24742677). Expressed in primary cilia of perivascular preadipocytes of white adipose tissue (at protein level) (PubMed:31761534). ; Abundant expression in the intestinal tract. Expressed in colonic intraepithelial neuroendocrine cells.

[Isoform 1]: Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Sorted to late endosome/lysosome compartments upon internalization. .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cell projection, cilium membrane ; Multi-pass membrane protein . Sorted to late endosome/lysosome compartments upon internalization (PubMed:22282525). Specifically localizes to the primary cilium of undifferentiated adipocytes. Ciliary trafficking is TULP3-dependent. As the cilium is lost during adipogenesis, moves to the plasma membrane (Probable). .

function:Receptor for unsaturated long-chain free fatty acid (FAA). Binding of the ligand promotes the secretion of glucagon-like peptide-1 from the gastro-intestinal tract.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Abundant expression in the intestinal tract.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.