产品名称
GPR119 Rabbit Polyclonal Antibody
别名
GPR119; Glucose-dependent insulinotropic receptor; G-protein coupled receptor 119
蛋白名称
Glucose-dependent insulinotropic receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=139760
Human Swissprot No.
Q8TDV5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TDV5/entry
Mouse Swissprot No.
Q7TQP3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TQP3
免疫原
The antiserum was produced against synthesized peptide derived from human GPR119. AA range:186-235
特异性
GPR119 Polyclonal Antibody detects endogenous levels of GPR119 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010],
组织表达
Predominantly expressed in the pancreas, especially in the islets.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in the pancreas, especially in the islets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
