产品名称
GNPAT Rabbit Polyclonal Antibody
别名
GNPAT; DAPAT; DHAPAT; Dihydroxyacetone phosphate acyltransferase; DAP-AT; DHAP-AT; Acyl-CoA:dihydroxyacetonephosphateacyltransferase; Glycerone-phosphate O-acyltransferase
蛋白名称
Dihydroxyacetone phosphate acyltransferase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8443
Human Swissprot No.
O15228
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15228/entry
Mouse Swissprot No.
P98192
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P98192
免疫原
The antiserum was produced against synthesized peptide derived from human GNPAT. AA range:231-280
特异性
GNPAT Polyclonal Antibody detects endogenous levels of GNPAT protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
组织表达
Aorta endothelial cell,Brain,Liver,Lung,Thymus,
细胞定位
Peroxisome membrane ; Peripheral membrane protein ; Matrix side . Exclusively localized to the lumenal side of the peroxisomal membrane. .
信号通路
Glycerophospholipid metabolism;
功能
catalytic activity:Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.,disease:Defects in GNPAT are the cause of rhizomelic chondrodysplasia punctata type 2 (RCDP2) [MIM:222765]. RDCP2 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,pathway:Membrane lipid metabolism; glycerophospholipid metabolism.,similarity:Belongs to the GPAT/DAPAT family.,subcellular location:Exclusively localized to the lumenal side of the peroxisomal membrane.,subunit:May be part of an heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
