产品名称
Glycerate Kinase Rabbit Polyclonal Antibody
别名
GLYCTK; HBEBP4; LP5910; Glycerate kinase; HBeAg-binding protein 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=132158
Human Swissprot No.
Q8IVS8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IVS8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=235582
Mouse Swissprot No.
Q8QZY2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8QZY2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=684314
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q0VGK3
免疫原
The antiserum was produced against synthesized peptide derived from human GLCTK. AA range:101-150
特异性
Glycerate Kinase Polyclonal Antibody detects endogenous levels of Glycerate Kinase protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009],
细胞定位
[Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm. Mitochondrion .
信号通路
Glycine; serine and threonine metabolism;Glycerolipid metabolism;Glyoxylate and dicarboxylate metabolism;
功能
catalytic activity:ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.,disease:Defects in GLYCTK are the cause of D-glyceric acidemia [MIM:220120]. It is characterized by nonketotic hyperglycinemia with the excretion of D-glyceric acid in the urine and the presence of this substance in the serum.,similarity:Belongs to the glycerate kinase type-2 family.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
