产品名称
GluR-δ2 Rabbit Polyclonal Antibody
别名
GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit
蛋白名称
Glutamate receptor delta-2 subunit
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2895
Human Swissprot No.
O43424
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43424/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14804
Mouse Swissprot No.
Q61625
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61625
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79220
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63226
免疫原
The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
特异性
GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this
组织表达
Brain,Cerebellum,PCR rescued clones,
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;Long-term depression;
功能
domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
