BD-PT1925

GluR-5 Rabbit Polyclonal Antibody

GRIK1; GLUR5; Glutamate receptor; ionotropic kainate 1; Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5

常规抗体

GRIK1

Glutamate receptor ionotropic kainate 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2897

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2897

P39086

http://www.uniprot.org/uniprotkb/P39086/entry

Q60934

http://www.uniprot.org/uniprot/Q60934

29559

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29559

P22756

http://www.uniprot.org/uniprot/P22756

The antiserum was produced against synthesized peptide derived from human GluR5. AA range:10-59

GluR-5 Polyclonal Antibody detects endogenous levels of GluR-5 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

100kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008],

Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Neuroactive ligand-receptor interaction;

alternative products:Additional isoforms seem to exist,function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA.,RNA editing:Partially edited.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5.,tissue specificity:Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.