产品名称
Glucagon Receptor Rabbit Polyclonal Antibody
别名
GCGR; Glucagon receptor; GL-R
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2642
Human Swissprot No.
P47871
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P47871/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14527
Mouse Swissprot No.
Q61606
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61606
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24953
Rat Swissprot Link
http://www.uniprot.org/uniprot/P30082
免疫原
The antiserum was produced against synthesized peptide derived from human GLR. AA range:95-144
特异性
Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010],
细胞定位
Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. .
信号通路
Neuroactive ligand-receptor interaction;
功能
disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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