产品名称
GLK Rabbit Polyclonal Antibody
别名
MAP4K3; RAB8IPL1; Mitogen-activated protein kinase kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3
蛋白名称
Mitogen-activated protein kinase kinase kinase kinase 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8491
Human Swissprot No.
Q8IVH8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IVH8/entry
Mouse Swissprot No.
Q99JP0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JP0
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170920
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q924I2
免疫原
The antiserum was produced against synthesized peptide derived from human MAP4K3. AA range:10-59
特异性
GLK Polyclonal Antibody detects endogenous levels of GLK protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
mitogen-activated protein kinase kinase kinase kinase 3(MAP4K3) Homo sapiens This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
组织表达
Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
细胞定位
intracellular,cytoplasm,
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.,tissue specificity:Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
