BD-PT1909

GIT2 Rabbit Polyclonal Antibody

GIT2; KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2

常规抗体

GIT2

ARF GTPase-activating protein GIT2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

9815

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9815

Q14161

http://www.uniprot.org/uniprotkb/Q14161/entry

26431

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26431

Q9JLQ2

http://www.uniprot.org/uniprot/Q9JLQ2

The antiserum was produced against synthesized peptide derived from human GIT2. AA range:361-410

GIT2 Polyclonal Antibody detects endogenous levels of GIT2 protein.

WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

84kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G

B-cell,Bone marrow,Cerebellum,Dermoid cancer,Epithelium,Skin,T-cell,

nucleoplasm,focal adhesion,

Endocytosis;

alternative products:Additional isoforms seem to exist,function:GTPase-activating protein for the ADP ribosylation factor family.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.