产品名称
GIMAP4 Rabbit Polyclonal Antibody
别名
GIMAP4; IAN1; IMAP4; MSTP062; GTPase IMAP family member 4; Immunity-associated nucleotide 1 protein; IAN-1; hIAN1; Immunity-associated protein 4
蛋白名称
GTPase IMAP family member 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55303
Human Swissprot No.
Q9NUV9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NUV9/entry
Mouse Swissprot No.
Q99JY3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JY3
免疫原
The antiserum was produced against synthesized peptide derived from human GIMAP4. AA range:131-180
特异性
GIMAP4 Polyclonal Antibody detects endogenous levels of GIMAP4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.
细胞定位
Cytoplasm, cytosol .
功能
function:Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.,similarity:Belongs to the IAN GTP-binding protein family.,tissue specificity:Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
