BD-PT1897

GFRα-4 Rabbit Polyclonal Antibody

GFRA4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor

常规抗体

GFRA4

GDNF family receptor alpha-4

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

64096

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64096

Q9GZZ7

http://www.uniprot.org/uniprotkb/Q9GZZ7/entry

Q9JJT2

http://www.uniprot.org/uniprot/Q9JJT2

The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190

GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

30kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.

alternative products:Additional isoforms seem to exist,function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.