产品名称
GDF-8 Rabbit Polyclonal Antibody
别名
MSTN; GDF8; Growth/differentiation factor 8; GDF-8; Myostatin
蛋白名称
Growth/differentiation factor 8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2660
Human Swissprot No.
O14793
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14793/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17700
Mouse Swissprot No.
O08689
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08689
免疫原
The antiserum was produced against synthesized peptide derived from human GDF-8. AA range:38-87
特异性
GDF-8 Polyclonal Antibody detects endogenous levels of GDF-8 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],
组织表达
Colon,Muscle,Pericardium,Skeletal muscle,
功能
function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
