产品名称
GCS-β-1 Rabbit Polyclonal Antibody
别名
GUCY1B3; GUC1B3; GUCSB3; GUCY1B1; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit
蛋白名称
Guanylate cyclase soluble subunit beta-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2983
Human Swissprot No.
Q02153
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q02153/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54195
Mouse Swissprot No.
O54865
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54865
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25202
Rat Swissprot Link
http://www.uniprot.org/uniprot/P20595
免疫原
The antiserum was produced against synthesized peptide derived from human Guanylate Cyclase beta. AA range:10-59
特异性
GCS-β-1 Polyclonal Antibody detects endogenous levels of GCS-β-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
组织表达
Detected in brain cortex and cerebellum (at protein level).
信号通路
Purine metabolism;Vascular smooth muscle contraction;Gap junction;Long-term depression;
功能
catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,cofactor:Binds 1 or 2 heme groups per heterodimer.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
