产品名称
GCS-α-1 Rabbit Polyclonal Antibody
别名
GUCY1A3; GUC1A3; GUCSA3; GUCY1A1; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit
蛋白名称
Guanylate cyclase soluble subunit alpha-3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2982
Human Swissprot No.
Q02108
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q02108/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60596
Mouse Swissprot No.
Q9ERL9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ERL9
Rat Swissprot Link
http://www.uniprot.org/uniprot/P19686
免疫原
The antiserum was produced against synthesized peptide derived from human GCS-alpha-1. AA range:374-423
特异性
GCS-α-1 Polyclonal Antibody detects endogenous levels of GCS-α-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
组织表达
Detected in brain cortex and lung (at protein level).
信号通路
Purine metabolism;Vascular smooth muscle contraction;Gap junction;Long-term depression;
功能
catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
