产品名称
GCSm-γ Rabbit Polyclonal Antibody
别名
GCLM; GLCLR; Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit
蛋白名称
Glutamate--cysteine ligase regulatory subunit
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2730
Human Swissprot No.
P48507
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48507/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14630
Mouse Swissprot No.
O09172
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O09172
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29739
Rat Swissprot Link
http://www.uniprot.org/uniprot/P48508
免疫原
The antiserum was produced against synthesized peptide derived from human GCSm-gamma. AA range:42-91
特异性
GCSm-γ Polyclonal Antibody detects endogenous levels of GCSm-γ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
组织表达
In all tissues examined. Highest levels in skeletal muscle.
细胞定位
cytosol,glutamate-cysteine ligase complex,
信号通路
Glutathione metabolism;
功能
pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.,similarity:Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.,subunit:Heterodimer of a catalytic heavy chain and a regulatory light chain.,tissue specificity:In all tissues examined. Highest levels in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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