产品名称
GCP4 Rabbit Polyclonal Antibody
别名
TUBGCP4; 76P; GCP4; Gamma-tubulin complex component 4; GCP-4; hGCP4; Gamma-ring complex protein 76 kDa; h76p; hGrip76
蛋白名称
Gamma-tubulin complex component 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27229
Human Swissprot No.
Q9UGJ1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UGJ1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51885
Mouse Swissprot No.
Q9D4F8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D4F8
免疫原
The antiserum was produced against synthesized peptide derived from human TUBGCP4. AA range:191-240
特异性
GCP4 Polyclonal Antibody detects endogenous levels of GCP4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015],
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
功能
function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.,similarity:Belongs to the GCP family.,subunit:Gamma-tubulin complex is composed of gamma-tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
