BD-PT1875-GCN5 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

GCN5 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT1875

产品名称

GCN5 Rabbit Polyclonal Antibody

别名

KAT2A; GCN5; GCN5L2; HGCN5; Histone acetyltransferase KAT2A; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97

类别

常规抗体

基因名称

KAT2A

蛋白名称

Histone acetyltransferase KAT2A

推荐应用

反应种属

Human,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

2648

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2648

Human Swissprot No.

Q92830

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q92830/entry

Mouse Gene ID

14534

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14534

Mouse Swissprot No.

Q9JHD2

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q9JHD2

免疫原

The antiserum was produced against synthesized peptide derived from human GCN5L2. AA range:691-740

特异性

GCN5 Polyclonal Antibody detects endogenous levels of GCN5 protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

预测分子量

100kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009],

组织表达

Expressed in all tissues tested.

细胞定位

Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). .

信号通路

Protein_Acetylation

功能

somitogenesis,?regionalization,?chromatin organization,?chromatin remodeling,?transcription,?transcription, DNA-dependent,?regulation of transcription, DNA-dependent,?regulation of transcription from RNA polymerase II promoter,transcription from RNA polymerase II promoter,?protein amino acid acetylation,?pattern specification process,embryonic development ending in birth or egg hatching,?anterior/posterior pattern formation,?chromatin modification,covalent chromatin modification,?histone modification,?histone acetylation,?histone deubiquitination,?protein deubiquitination,?RNA biosynthetic process,?segmentation,?chordate embryonic development,?protein amino acid acylation,?histone H3 acetylation,?regulation of transcription,?regulation of RNA metabolic process,?chromosome organization,?protein modification by small protein removal,?protein modification by small protein conjugation or removal,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysates from mouse brain, using GCN5L2 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of the lysates from RAW264.7cells using GCN5L2 antibody.

Western Blot analysis of various cells using GCN5 Polyclonal Antibody diluted at 1：1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Western Blot analysis of Hela cells using GCN5 Polyclonal Antibody diluted at 1：1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100（4°,overnight）. High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl （right） obtaned from antibody was pre-absorbed by immunogen peptide.