产品名称
GCKR Rabbit Polyclonal Antibody
别名
GCKR; Glucokinase regulatory protein; Glucokinase regulator
蛋白名称
Glucokinase regulatory protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2646
Human Swissprot No.
Q14397
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14397/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231103
Mouse Swissprot No.
Q91X44
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91X44
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25658
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q07071
免疫原
The antiserum was produced against synthesized peptide derived from human Glucokinase Regulator. AA range:211-260
特异性
GCKR Polyclonal Antibody detects endogenous levels of GCKR protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008],
组织表达
Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
细胞定位
Cytoplasm . Nucleus . Mitochondrion . Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. .
功能
function:Inhibits glucokinase by forming an inactive complex with this enzyme.,similarity:Belongs to the GCKR family.,similarity:Contains 1 SIS domain.,tissue specificity:Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
