产品名称
GBP1 Rabbit Polyclonal Antibody
别名
GBP1; Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1
蛋白名称
Interferon-induced guanylate-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2633
Human Swissprot No.
P32455
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P32455/entry
Mouse Swissprot No.
Q01514
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q01514
免疫原
The antiserum was produced against synthesized peptide derived from human GBP1. AA range:71-120
特异性
GBP1 Polyclonal Antibody detects endogenous levels of GBP1 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008],
组织表达
Placenta,Spleen,Uterus,
细胞定位
Cytoplasm . Golgi apparatus membrane; Lipid-anchor ; Cytoplasmic side. Cell membrane . Secreted . Cytoplasmic vesicle . Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
功能
function:Binds GTP, GDP and GMP.,induction:By interferon gamma during macrophage activation.,similarity:Belongs to the GBP family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
