产品名称
GAP1-InsP4 BP Rabbit Polyclonal Antibody
别名
RASA3; Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein
蛋白名称
Ras GTPase-activating protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22821
Human Swissprot No.
Q14644
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14644/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19414
Mouse Swissprot No.
Q60790
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60790
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29372
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9QYJ2
免疫原
The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296
特异性
GAP1-InsP4 BP Polyclonal Antibody detects endogenous levels of GAP1-InsP4 BP protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
组织表达
Blood,Brain,Peripheral blood,Platelet,Testis,
功能
function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
