产品名称
GALR2 Rabbit Polyclonal Antibody
别名
GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2
蛋白名称
Galanin receptor type 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8811
Human Swissprot No.
O43603
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43603/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14428
Mouse Swissprot No.
O88854
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88854
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100910349
Rat Swissprot Link
http://www.uniprot.org/uniprot/O08726
免疫原
The antiserum was produced against synthesized peptide derived from human GALR2. AA range:201-250
特异性
GALR2 Polyclonal Antibody detects endogenous levels of GALR2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul
组织表达
Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via Gq) and that inhibit adenylyl cyclase (via Gi).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
