产品名称
GALK1 Rabbit Polyclonal Antibody
别名
GALK1; GALK; Galactokinase; Galactose kinase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2584
Human Swissprot No.
P51570
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51570/entry
Mouse Swissprot No.
Q9R0N0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0N0
免疫原
The antiserum was produced against synthesized peptide derived from human GALK1. AA range:1-50
特异性
GALK1 Polyclonal Antibody detects endogenous levels of GALK1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008],
组织表达
Blood,Brain,Fetal brain cortex,Lung,
细胞定位
cytoplasm,cytosol,membrane,extracellular exosome,
信号通路
Galactose metabolism;Amino sugar and nucleotide sugar metabolism;
功能
catalytic activity:ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate.,disease:Defects in GALK1 are the cause of galactosemia II [MIM:230200]. It is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.,function:Major enzyme for galactose metabolism.,pathway:Carbohydrate metabolism; galactose metabolism.,similarity:Belongs to the GHMP kinase family.,similarity:Belongs to the GHMP kinase family. GalK subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
