产品名称
Galectin-9 Rabbit Polyclonal Antibody
别名
LGALS9; Galectin-9; Gal-9; Ecalectin; Tumor antigen HOM-HD-21
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3965
Human Swissprot No.
O00182
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O00182/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16859
Mouse Swissprot No.
O08573
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08573
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25476
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97840
免疫原
The antiserum was produced against synthesized peptide derived from human LEG9. AA range:51-100
特异性
Galectin-9 Polyclonal Antibody detects endogenous levels of Galectin-9 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).
细胞定位
Cytoplasm . Nucleus . Secreted . May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .
功能
alternative products:Additional isoforms seem to exist,domain:Contains two homologous but distinct carbohydrate-binding domains.,function:Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. The isoform Short acts as an eosinophil chemoattractant. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death.,online information:Galectin-9,similarity:Contains 2 galectin domains.,subcellular location:May also be secreted by a non-classical secretory pathway.,subunit:Monomer.,tissue specificity:Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin's disease tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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