产品名称
Gads Rabbit Polyclonal Antibody
别名
GRAP2; GADS; GRB2L; GRID; GRB2-related adapter protein 2; Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein Grp
蛋白名称
GRB2-related adapter protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9402
Human Swissprot No.
O75791
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75791/entry
Mouse Swissprot No.
O89100
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O89100
免疫原
The antiserum was produced against synthesized peptide derived from human GRAP2. AA range:121-170
特异性
Gads Polyclonal Antibody detects endogenous levels of Gads protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
组织表达
Blood,Lung,Platelet,Spleen,T-cell,Thymus,
细胞定位
Nucleus . Cytoplasm . Endosome .
功能
function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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