产品名称
GADD 45γ Rabbit Polyclonal Antibody
别名
GADD45G; CR6; DDIT2; Growth arrest and DNA damage-inducible protein GADD45 gamma; Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2
蛋白名称
Growth arrest and DNA damage-inducible protein GADD45 gamma
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10912
Human Swissprot No.
O95257
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95257/entry
Mouse Swissprot No.
Q9Z111
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z111
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291005
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9WTQ7
免疫原
The antiserum was produced against synthesized peptide derived from human GA45G. AA range:101-150
特异性
GADD 45γ Polyclonal Antibody detects endogenous levels of GADD 45γ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008],
组织表达
Brain,Colon carcinoma,Lung,Placenta,
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;p53;
功能
function:Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
