产品名称
GABAA Rγ1 Rabbit Polyclonal Antibody
别名
GABRG1; Gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor subunit gamma-1
蛋白名称
Gamma-aminobutyric acid receptor subunit gamma-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2565
Human Swissprot No.
Q8N1C3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N1C3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14405
Mouse Swissprot No.
Q9R0Y8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0Y8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140674
Rat Swissprot Link
http://www.uniprot.org/uniprot/P23574
免疫原
The antiserum was produced against synthesized peptide derived from human GABRG1. AA range:11-60
特异性
GABAA Rγ1 Polyclonal Antibody detects endogenous levels of GABAA Rγ1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008],
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,miscellaneous:This subunit carries the benzodiazepine binding site.,online information:Forbidden fruit - Issue 56 of March 2005,PTM:May be palmitoylated.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
