产品名称
GABAA Rβ2 Rabbit Polyclonal Antibody
别名
GABRB2; Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2
蛋白名称
Gamma-aminobutyric acid receptor subunit beta-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2561
Human Swissprot No.
P47870
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P47870/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14401
Mouse Swissprot No.
P63137
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63137
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25451
Rat Swissprot Link
http://www.uniprot.org/uniprot/P63138
免疫原
The antiserum was produced against synthesized peptide derived from human GABAA Rbeta2. AA range:382-431
特异性
GABAA Rβ2 Polyclonal Antibody detects endogenous levels of GABAA Rβ2 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008],
组织表达
Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
细胞定位
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
