产品名称
GABAA Rα6 Rabbit Polyclonal Antibody
别名
GABRA6; Gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor subunit alpha-6
蛋白名称
Gamma-aminobutyric acid receptor subunit alpha-6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2559
Human Swissprot No.
Q16445
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16445/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14399
Mouse Swissprot No.
P16305
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P16305
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29708
Rat Swissprot Link
http://www.uniprot.org/uniprot/P30191
免疫原
The antiserum was produced against synthesized peptide derived from human GABRA6. AA range:61-110
特异性
GABAA Rα6 Polyclonal Antibody detects endogenous levels of GABAA Rα6 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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