产品名称
GABAA Rα4 Rabbit Polyclonal Antibody
别名
GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4
蛋白名称
Gamma-aminobutyric acid receptor subunit alpha-4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2557
Human Swissprot No.
P48169
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48169/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14397
Mouse Swissprot No.
Q9D6F4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D6F4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140675
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28471
免疫原
The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130
特异性
GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
