产品名称
GABA T-1 Rabbit Polyclonal Antibody
别名
SLC6A1; GABATR; GABT1; GAT1; Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1
蛋白名称
Sodium- and chloride-dependent GABA transporter 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6529
Human Swissprot No.
P30531
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30531/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=232333
Mouse Swissprot No.
P31648
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P31648
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79212
Rat Swissprot Link
http://www.uniprot.org/uniprot/P23978
免疫原
The antiserum was produced against synthesized peptide derived from human SLC6A1. AA range:381-430
特异性
GABA T-1 Polyclonal Antibody detects endogenous levels of GABA T-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009],
细胞定位
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). .
功能
domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
