产品名称
Gab 2 Rabbit Polyclonal Antibody
别名
GAB2; KIAA0571; GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
蛋白名称
GRB2-associated-binding protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846
Human Swissprot No.
Q9UQC2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UQC2/entry
Mouse Swissprot No.
Q9Z1S8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1S8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84477
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9EQH1
免疫原
The antiserum was produced against synthesized peptide derived from human Gab2. AA range:589-638
特异性
Gab 2 Polyclonal Antibody detects endogenous levels of Gab 2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],
组织表达
Brain,Clones donated by Kazusa DNA Research Inst.,
细胞定位
Cytoplasm . Cell membrane .
信号通路
Fc epsilon RI;Fc gamma R-mediated phagocytosis;Chronic myeloid leukemia;
功能
PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2, PI-3 kinase and with other SH2-containing proteins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
