产品名称
GABAA Rα6 Rabbit Polyclonal Antibody
别名
GABRA6; Gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor subunit alpha-6
蛋白名称
Gamma-aminobutyric acid receptor subunit alpha-6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2559
Human Swissprot No.
Q16445
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16445/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14399
Mouse Swissprot No.
P16305
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P16305
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29708
Rat Swissprot Link
http://www.uniprot.org/uniprot/P30191
免疫原
The antiserum was produced against synthesized peptide derived from human GABRA6. AA range:61-110
特异性
GABAA Rα6 Polyclonal Antibody detects endogenous levels of GABAA Rα6 protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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