产品名称
FX Rabbit Polyclonal Antibody
别名
TSTA3; SDR4E1; GDP-L-fucose synthase; GDP-4-keto-6-deoxy-D-mannose-3; 5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Short-chain dehydrogenase/reductase family 4E member 1
蛋白名称
GDP-L-fucose synthase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7264
Human Swissprot No.
Q13630
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13630/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22122
Mouse Swissprot No.
P23591
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P23591
免疫原
The antiserum was produced against synthesized peptide derived from human TSTA3. AA range:221-270
特异性
FX Polyclonal Antibody detects endogenous levels of FX protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008],
组织表达
Erythrocyte,Lung,Placenta,Skin,
细胞定位
cytoplasm,cytosol,extracellular exosome,
信号通路
Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;
功能
catalytic activity:GDP-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-D-mannose + NADPH.,function:Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.,pathway:Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-D-mannose: step 2/2.,similarity:Belongs to the fucose synthetase family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
