产品名称
FRS3 Rabbit Polyclonal Antibody
别名
FRS3; Fibroblast growth factor receptor substrate 3; FGFR substrate 3; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2
蛋白名称
Fibroblast growth factor receptor substrate 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10817
Human Swissprot No.
O43559
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43559/entry
Mouse Swissprot No.
Q91WJ0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91WJ0
免疫原
The antiserum was produced against synthesized peptide derived from human FRS3. AA range:191-240
特异性
FRS3 Polyclonal Antibody detects endogenous levels of FRS3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013],
细胞定位
Membrane; Lipid-anchor.
功能
function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.,PTM:Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.,similarity:Contains 1 IRS-type PTB domain.,subunit:Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
