BD-PT1792

FRS2 Rabbit Polyclonal Antibody

FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1

常规抗体

FRS2

Fibroblast growth factor receptor substrate 2

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10818

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10818

Q8WU20

http://www.uniprot.org/uniprotkb/Q8WU20/entry

327826

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=327826

Q8C180

http://www.uniprot.org/uniprot/Q8C180

The antiserum was produced against synthesized peptide derived from human FRS2. AA range:402-451

FRS2 Polyclonal Antibody detects endogenous levels of FRS2 protein.

WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

85kD

-20°C/1 year

Polyclonal, Rabbit,IgG

function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Endomembrane system. Cytoplasmic, membrane-bound.

Neurotrophin;

function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.