产品名称
FPR1 Rabbit Polyclonal Antibody
别名
FPR1; fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor
蛋白名称
fMet-Leu-Phe receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2357
Human Swissprot No.
P21462
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P21462/entry
Mouse Swissprot No.
P33766
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P33766
免疫原
The antiserum was produced against synthesized peptide derived from human FPR1. AA range:155-204
特异性
FPR1 Polyclonal Antibody detects endogenous levels of FPR1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
formyl peptide receptor 1(FPR1) Homo sapiens This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010],
细胞定位
Cell membrane ; Multi-pass membrane protein . Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG. .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.,PTM:Phosphorylated; which is necessary for desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Neutrophils.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
