产品名称
Fos B Rabbit Polyclonal Antibody
别名
FOSB; G0S3; Protein fosB; G0/G1 switch regulatory protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2354
Human Swissprot No.
P53539
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P53539/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14282
Mouse Swissprot No.
P13346
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P13346
免疫原
The antiserum was produced against synthesized peptide derived from human FosB. AA range:12-61
特异性
Fos B Polyclonal Antibody detects endogenous levels of Fos B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
[Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level).
功能
function:FosB interacts with Jun proteins enhancing their DNA binding activity.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
