产品名称
FKBPL Rabbit Polyclonal Antibody
别名
FKBPL; DIR1; NG7; FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; WISp39
蛋白名称
FK506-binding protein-like
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63943
Human Swissprot No.
Q9UIM3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UIM3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56299
Mouse Swissprot No.
O35450
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35450
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=406168
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6MG81
免疫原
The antiserum was produced against synthesized peptide derived from human FKBPL. AA range:251-300
特异性
FKBPL Polyclonal Antibody detects endogenous levels of FKBPL protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed with higher levels in testis.
细胞定位
endoplasmic reticulum membrane,cytosol,
功能
function:May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 TPR repeats.,subunit:Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.,tissue specificity:Ubiquitously expressed with higher levels in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
