产品名称
Fibulin-3 Rabbit Polyclonal Antibody
别名
EFEMP1; FBLN3; FBNL; EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3
蛋白名称
EGF-containing fibulin-like extracellular matrix protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2202
Human Swissprot No.
Q12805
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q12805/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216616
Mouse Swissprot No.
Q8BPB5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BPB5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35568
免疫原
The antiserum was produced against synthesized peptide derived from human EFEMP1. AA range:111-160
特异性
Fibulin-3 Polyclonal Antibody detects endogenous levels of Fibulin-3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009],
组织表达
In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
细胞定位
Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . Localizes to the lamina propria underneath the olfactory epithelium. .
功能
alternative products:Experimental confirmation may be lacking for some isoforms,disease:Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT OR ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the fibulin family.,similarity:Contains 6 EGF-like domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
