BD-PC0007

Cleaved-Caspase-6 p18 (D162) Rabbit Polyclonal Antibody

CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

常规抗体

CASP6

Caspase6

WB

Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

12368

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12368

O35397

http://www.uniprot.org/uniprot/O35397

The antiserum was produced against synthesized peptide derived from mouse Caspase 6. AA range:144-193

Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-6 p18 protein resulting from cleavage adjacent to D162.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

28+35kD

-20°C/1 year

Polyclonal, Rabbit,IgG

CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.