产品名称
FGFR-5 Rabbit Polyclonal Antibody
别名
FGFRL1; FGFR5; FHFR; Fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5
蛋白名称
Fibroblast growth factor receptor-like 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53834
Human Swissprot No.
Q8N441
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N441/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116701
Mouse Swissprot No.
Q91V87
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91V87
免疫原
Synthesized peptide derived from FGFR-5 . at AA range: 130-210
特异性
FGFR-5 Polyclonal Antibody detects endogenous levels of FGFR-5 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other
组织表达
Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
细胞定位
Membrane ; Single-pass type I membrane protein . Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
功能
function:Has a negative effect on cell proliferation.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.,subunit:Interacts with FGF2 with a low affinity.,tissue specificity:Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
