产品名称
FGF-13 Rabbit Polyclonal Antibody
别名
FGF13; FHF2; Fibroblast growth factor 13; FGF-13; Fibroblast growth factor homologous factor 2; FHF-2
蛋白名称
Fibroblast growth factor 13
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2258
Human Swissprot No.
Q92913
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92913/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14168
Mouse Swissprot No.
P70377
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70377
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84488
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9ERW3
免疫原
The antiserum was produced against synthesized peptide derived from human FGF13. AA range:154-203
特异性
FGF-13 Polyclonal Antibody detects endogenous levels of FGF-13 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008],
组织表达
Ubiquitously expressed. Predominantly expressed in the nervous system.
细胞定位
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . Nucleus .; [Isoform 3]: Cytoplasm . Nucleus .; [Isoform 4]: Cytoplasm . Nucleus .; [Isoform 5]: Cytoplasm . Nucleus .; Cell projection, filopodium . Cell projection, growth cone . Cell projection, dendrite . Cell membrane, sarcolemma . Cytoplasm . Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;
功能
function:Probably involved in nervous system development and function.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Nervous system.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
